Repair of esophageal full-thickness defects with expanded polytetrafluoroethylene (PTFE) patch an experimental study on dogs.

摘要

To test the suitability of polytetrafluoroethylene (PTFE) for repair of full-thickness defects in esophageal wall, eight mixed breed male dogs were utilized in this study. Anesthesia was induced by diazepam and sodium thiopental and maintained by halothane and oxygen. Ringers lactate was administered throughout the surgery. After exposing of cervical esophagus, a full-thickness defect (3x2 cm) was made and it was closed by PTFE patch placed in luminal side and fixed by prolene sutures. No dysphagia or aphagia was shown after the surgery and PTFE was absent at the luminal side of 5 dogs suggesting the passage of the prosthesis to the stomach. In 3 dogs, PTFE was adherent to its surrounding tissues by sutures. Luminal wall consistency was normal, no stricture was noticed and microscopically, a good regeneration and a complete epithelialization were observed. It is concluded that PTFE can be considered as a suitable prosthesis for reconstruction of full thickness esophageal wall defects..