Segregation of resin-bound peptides during solid-phase synthesis

摘要

To compare the segregation ability of 1,4-butanediol dimethacrylate-crosslinked polystyrene (BDDMA-PS) and divinylbenzene-crosslinked polystyrene (DVB-PS), a set of difficult sequence peptides characterized by high-arithmetic-average beta-sheet stabilizing potential (SPbeta) and low-stepwise arithmetic average random coil conformational parameter (P-c*) were synthesized on both supports (similar to 2 mmol Cl g(-1)) under identical conditions. The yield and purity of the peptides obtained from BDDMS-PS resin were higher than from DVB-PS resin. The synthetic efficiency of the new support was found to be its ability to suppress the aggregation of growing peptide chain; by beta-sheet formation. (C) 2002 Wiley Periodicals, Inc. [References: 27]