Preparation of Resin-Bound Bismethylene Cyclic Malonic Acid Ester and Facile Solid-Phase Synthesis of 2-Alkylthio-4(1H)-quinolone synthesis of 2-Alkyl-4(1H)-quinolone

摘要

The resin-bound bismethylthiomethylene cycilc malonic acid ester 3 was built up efficiently.resin 3 can react with arylamines and subsequent thermal cyclizations give 2-alkylthio-4-(1H)-quinolones.Furthermore,conjugate addition of Grignard reagents to the resin 3 forms the resin 6 which was reacted with aryl amines and subsequent thermal-cyclization-cleavages affrod the 2-alkyl-4(1H)-quinolones.