QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP FOR THE EFFECT OF BENZOIC ACIDS, CINNAMIC ACIDS AND BENZALDEHYDES ON LISTERIA MONOCYTOGENES

摘要

The inhibition of a cocktail of 18 strains of Listeria monocytogenes by 24 mono-, di- and tri-substituted benzoic and cinnamic acids and 16 benzaldehydes was evaluated using the concentration (C) required to give a 50% growth inhibition under anaerobic conditions at 35 degrees C and pH 6.2 as a measure of biological activity (BAV), Using the method of least squares, multiple regression equations were obtained which described the contribution of some physicochemical and other structural properties of the compounds to their biological activity. The equation that best described the activity of benzoic and cinnamic acids was