Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Tang W. H. Wilson; Wang Zeneng; Kennedy David J.; Wu Yuping; Buffa Jennifer A.; Agatisa-Boyle Brendan; Li Xinmin S.; Levison Bruce S.; Hazen Stanley L.

首页> 外文期刊>Circulation research: a journal of the American Heart Association >Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

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Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

机译：肠道菌群依赖的三甲胺N-氧化物（TMAO）通路有助于慢性肾病的肾功能不全和死亡率风险的发展。

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Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

机译：理由：三甲胺-N-氧化物（TMAO）是膳食胆碱，磷脂酰胆碱（卵磷脂）和L-肉碱的肠道微生物依赖性代谢产物，在慢性肾脏疾病（CKD）中升高，并与冠状动脉疾病的发病机理有关。

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《Circulation research: a journal of the American Heart Association 》 |2015年第3期| 共8页
作者
Tang W. H. Wilson; Wang Zeneng; Kennedy David J.; Wu Yuping; Buffa Jennifer A.; Agatisa-Boyle Brendan; Li Xinmin S.; Levison Bruce S.; Hazen Stanley L.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病 ;
关键词
cardiovascular diseases; chronic kidney disease; fibrosis; gut microbiota; trimethylamine N-oxide;

机译：心血管疾病;慢性肾脏疾病;纤维化;肠道菌群;三甲胺N-氧化物;

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1. Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease [J] . Tang W. H. Wilson, Wang Zeneng, Kennedy David J., Circulation research: a journal of the American Heart Association . 2015 ,第3期

机译：肠道菌群依赖的三甲胺N-氧化物（TMAO）通路有助于慢性肾病的肾功能不全和死亡率风险的发展。
2. Blood Pressure and Risk of All-Cause Mortality in Advanced Chronic Kidney Disease and Hemodialysis The Chronic Renal Insufficiency Cohort Study [J] . Bansal Nisha, McCulloch Charles E., Rahman Mahboob, Hypertension: An Official Journal of the American Heart Association . 2015 ,第1期

机译：慢性肾脏病和血液透析患者的血压和全因死亡率风险慢性肾功能不全队列研究
3. Long-term mortality and risk factors for development of end-stage renal disease in critically ill patients with and without chronic kidney disease [J] . Claire Rimes-Stigare, Paolo Frumento, Matteo Bottai, Critical care : . 2015 ,第1期

机译：患有和不患有慢性肾脏病的危重患者的长期死亡率和发展为终末期肾脏疾病的危险因素
4. CHRONIOUS: An open, ubiquitous and adaptive chronic disease management platform for Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD) and renal insufficiency [C] . Rosso R., Munaro G., Salvetti O., 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：慢性病：针对慢性阻塞性肺疾病（COPD），慢性肾脏病（CKD）和肾功能不全的开放，无处不在的适应性慢性疾病管理平台
5. Subtyping Chronic Kidney Disease Patients and Adiposity-Obesity Related Metabolomics Analyses: Findings from the Chronic Renal Insufficiency Cohort Study [D] . Zheng, Zihe. 2021

机译：亚型慢性肾病患者和肥胖肥胖相关的代谢组科分析：从慢性肾功能不全的研究结果研究
6. Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease [O] . W. H. Wilson Tang, Zeneng Wang, David J. Kennedy, -1

机译：肠道菌群依赖性三甲胺N-氧化物（TMAO）通路有助于慢性肾病的肾功能不全和死亡率风险的发展。
7. Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease [O] . Nilaksh Gupta, Jennifer A. Buffa, Adam B. Roberts, 2020

机译：肠道微生物三甲胺N-氧化物产生的靶向抑制可降低慢性肾病的鼠模型中的肾微管腹纤维化和功能损伤

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

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