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Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

机译：肠道菌群依赖性三甲胺N-氧化物（TMAO）通路有助于慢性肾病的肾功能不全和死亡率风险的发展。

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RationaleTrimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin) and L-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

机译：基本原理三甲胺-N-氧化物（TMAO）是膳食胆碱，磷脂酰胆碱（卵磷脂）和L-肉碱的肠道微生物依赖性代谢产物，在慢性肾脏疾病（CKD）中升高，并与冠状动脉疾病的发病机理有关。

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期刊名称 other
作者
W. H. Wilson Tang; Zeneng Wang; David J. Kennedy; Yuping Wu; Jennifer A. Buffa; Brendan Agatisa-Boyle; Xinmin S. Li; Bruce S. Levison; Stanley L. Hazen;
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作者单位

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年(卷),期 -1(116),3
年度 -1
页码 448–455
总页数 18
原文格式 PDF
正文语种
中图分类
关键词
Trimethylamine N-oxide renal insufficiency fibrosis cardiovascular disease gut microbiota;

机译：N-三甲胺氧化物;肾功能不全;纤维化;心血管疾病;肠道菌群;

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专利

1. Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease [J] . Tang W. H. Wilson, Wang Zeneng, Kennedy David J., Circulation research: a journal of the American Heart Association . 2015,第3期

机译：肠道菌群依赖的三甲胺N-氧化物（TMAO）通路有助于慢性肾病的肾功能不全和死亡率风险的发展。
2. Blood Pressure and Risk of All-Cause Mortality in Advanced Chronic Kidney Disease and Hemodialysis The Chronic Renal Insufficiency Cohort Study [J] . Bansal Nisha, McCulloch Charles E., Rahman Mahboob, Hypertension: An Official Journal of the American Heart Association . 2015,第1期

机译：慢性肾脏病和血液透析患者的血压和全因死亡率风险慢性肾功能不全队列研究
3. Blood Pressure and Risk of All-Cause Mortality in Advanced Chronic Kidney Disease and Hemodialysis The Chronic Renal Insufficiency Cohort Study [J] . Bansal Nisha, McCulloch Charles E., Rahman Mahboob, Hypertension: An Official Journal of the American Heart Association . 2015,第1期

机译：慢性肾脏病和血液透析患者的血压和全因死亡率风险慢性肾功能不全队列研究
4. CHRONIOUS: An open, ubiquitous and adaptive chronic disease management platform for Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD) and renal insufficiency [C] . Rosso R., Munaro G., Salvetti O., 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：慢性病：针对慢性阻塞性肺疾病（COPD），慢性肾脏病（CKD）和肾功能不全的开放，无处不在的适应性慢性疾病管理平台
5. Subtyping Chronic Kidney Disease Patients and Adiposity-Obesity Related Metabolomics Analyses: Findings from the Chronic Renal Insufficiency Cohort Study [D] . Zheng, Zihe. 2021

机译：亚型慢性肾病患者和肥胖肥胖相关的代谢组科分析：从慢性肾功能不全的研究结果研究
6. Gut Microbiota-Dependent Trimethylamine N-Oxide Pathway Associated with Cardiovascular Risk in Children with Early-Stage Chronic Kidney Disease [O] . Chien-Ning Hsu, Pei-Chen Lu, Mao-Hung Lo, 1999

机译：肠道菌群依赖的三甲胺N-氧化物途径与早期慢性肾脏病患儿的心血管风险相关
7. Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease [O] . Nilaksh Gupta, Jennifer A. Buffa, Adam B. Roberts, 2020

机译：肠道微生物三甲胺N-氧化物产生的靶向抑制可降低慢性肾病的鼠模型中的肾微管腹纤维化和功能损伤

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

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