Spectrophotometry determination of metronidazole and tinidazole by their complexation with copper(II)

摘要

It is shown that the treatment of chloroform solutions of drugs of the nitroimidazole series (NIm) with crystalline copper(II) acetate gives colored chloroform-soluble adducts of the general formula [Cu(CH_3COO) _2NIm]_2, which can be used as analytical forms in the spectrophotometry determination of metronidazole and tinidazole. The respective analytical methods are developed and certified.