The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss A Randomized Clinical Trial

Bednar Martin M.; DeMartinis Nick; Banerjee Anindita; Bowditch Stephen; Gaudreault Francois; Zumpano Laura; Lin Frank R.

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The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss A Randomized Clinical Trial

机译：PF-04958242在与年龄有关的感觉神经性听力损失中的安全性和有效性-一项随机临床试验

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IMPORTANCE To our knowledge, this is the first study to assess the potential to pharmacologically improve auditory function in adults with age-related sensorineural hearing loss.

机译：重要信息据我们所知，这是第一项评估在药理学上改善与年龄相关的感音神经性听力丧失的成年人听觉功能的潜力的研究。

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《JAMA otolaryngology-- head & neck surgery》 |2015年第7期|共7页
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Bednar Martin M.; DeMartinis Nick; Banerjee Anindita; Bowditch Stephen; Gaudreault Francois; Zumpano Laura; Lin Frank R.;
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正文语种 eng
中图分类耳鼻咽喉科学;
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1. The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss A Randomized Clinical Trial [J] . Bednar Martin M., DeMartinis Nick, Banerjee Anindita, JAMA otolaryngology-- head & neck surgery . 2015,第7期

机译：PF-04958242在与年龄有关的感觉神经性听力损失中的安全性和有效性-一项随机临床试验
2. In reference to Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy (Laryngoscope 119:359-369, 2009). [J] . Nakashima T, Teranishi M, Yoshida T The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2009,第12期

机译：参照随机，双盲，安慰剂对照试验，探讨通过圆窗导管递送持续鼓膜内地塞米松治疗系统治疗失败后重度至重度特发性特发性感音神经性听力损失的安全性和有效性（喉镜119：359-369，2009）。
3. Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemi [J] . Plontke SK, Lowenheim H, Mertens J, The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2009,第2期

机译：随机，双盲，安慰剂对照试验，关于通过圆窗导管递送持续鼓膜内地塞米松治疗系统性衰竭后重度至重度特发性特发性感音神经性听力损失的安全性和有效性
4. Digital Hearing Aid for Sensorineural Hearing Loss : (Ski-Slope Hearing Loss) [C] . K Arpitha Nagesh, P Kavya, B K Kavyashree, 2017 International Conference on Current Trends in Computer, Electrical, Electronics and Communication . 2017

机译：用于感觉神经性听力损失的数字助听器：（滑雪坡听力损失）
5. Sequential Rematched Randomization and Adaptive Monitoring with the Second-Generation p-Value to Increase the Efficiency and Efficacy of Randomized Clinical Trials [D] . Chipman, Jonathan Joseph. 2019

机译：用第二代P值进行顺序重复随机化和自适应监测，以提高随机临床试验的效率和功效
6. Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients [O] . Ho Seok Lee, Woo Jin Kim, Ji Sun Gong, 2018

机译：自体骨髓源间充质干细胞移植在感觉神经性听力损失患者中的临床安全性和有效性
7. A phase 3, placebo controlled, double-blind, randomized study for assessing the efficacy and safety of corticosteroids and magnesium supplement in patients with sudden sensorineural hearing loss [O] . Μπάτζιου Νικολέτα 2016

机译：一项3期，安慰剂对照，双盲，随机研究，以评估皮质类固醇和镁补充剂对突发性感音神经性聋患者的疗效和安全性。

The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss A Randomized Clinical Trial

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