Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3'-oxindole] Compounds

摘要

A series of spiro [pyrrolidine-2,3'-oxindole] derivatives Were synthesized by 1,3-dipolar cycloadditionreaction of isatin, a-amino acid and (E)-β-substituted-styrene. Four kinds' of trapping dipolarophiles were introducedinto this reaction, and the regioselectivity of these reactions proved to be the same fashion. Bioactivity screeningshowed these compounds were active on anti-tumor in A549 and P388 cell line, and several compounds were found tobe active under the condensation of 10~(-4)M.