DIRECT CATALYTIC ASYMMETRIC VINYLOGOUS MICHAEL REACTION OF α,β-UNSATURATED γ-BUTYROLACTAM UNDER DINUCLEAR NICKEL SCHIFF BASE CATALYSIS

摘要

Direct catalytic asymmetric vinylogous Michael reaction is described. 2.5 mol % of homobimetallic (S)-Ni2-Schiff base complex efficiently catalyzed the addition of α,β-unsaturated γ-butyrolactam to nitroalkenes under simple proton transfer conditions, giving vinylogous Michael products in 83-99% yield, 16:1->30:1 dr, and 96-99% ee.