An efficient synthesis of optically active 2-[4-(6-chloro-2-quinoxalinyloxy)-phenoxy]-propionamide derivatives

摘要

An efficient synthesis of (R)-(+)-2-[4-(6-chloro-2-quinoxalinyloxy)-phenoxy] -propion-amide 4a-e is described by simple amidation of Quizalofop-methyl (R) [(R)-(+)-3]. The reduced susceptibility of quinoxalinyl moiety of (R)-(+)-3 toward nucleophilic reagents was discussed on the basis of QM calculation.