AN EFFECTIVE KINETIC RESOLUTION OF RACEMIC SECONDARY BENZYLIC ALCOHOLS USING 3-PYRIDINECARBOXYLIC ANHYDRIDE AND A CHIRAL ACYL-TRANSFER CATALYST IN THE ABSENCE OF TERTIARY AMINE

摘要

3-Pyridinecarboxylic anhydride (3-PCA) was found to function as an efficient coupling reagent for the kinetic resolution of racemic secondary benzylic alcohols with achiral carboxylic acids in the presence of a catalytic amount of (+)-BTM. A variety of optically active carboxylic esters are produced with high enantiomeric excesses by this new chiral induction system without using a tertiary amine.