Synthesis of 2,4-diarylimidazoles through suzuki cross-coupling reactions of imidazole halides with arylboronic acids

摘要

The Suzuki coupling,a Pd-catalyzed cross-coupling reaction of a boronic acid with an aryl halide,was used to prepare several 2,4-diarylimidazoles.lodinated and brominated imidazoles (3) and (9) proved to be suitable aryl halides for Suzuki coupling.These imidazole halides readily reacted with phenyl-,naphthyl- and biphenylboronic acids under Suzuki conditions to give arylated imidazoles.