Synthesis Of Mycalamide Analogs

摘要

Several new artificial analogs(3-6)of mycalamide A(1),a potent antiviral and antitumor agent,were synthesized through a coupling reaction of a bicyclic amine(19)with two tetrahydropyrancarboxylic acids(15)and(18),and their cytotoxicity and antiviral activity were tested.