Electrophilic reaction of N-lewis acid and n-oxide lewis acid complexes of 4-methylpyridines and their tv-oxides through base-induced deprotonation

摘要

The comparative studies were carried out on the relative reactivity of 4-methylpyridines,their N-oxides and their Lewis acid complexes towards electrophilic reaction,alpha-Deprotonation in pyridine ring rather than deprotonation of active methyl group or metal-halogen exchange occurred preferentially in the reaction of N-and N-oxides BFa complexes with electrophile in the presence of LTMP-TMEDA in THF to give a-substituted-4-methylpyridines and their TV-oxides.