FORMAL SYNTHESIS OF (+-)-TRACHELANTHAMIDINE

摘要

Base-induced coupling-cyclization stepwise [3+2] annulation of alpha-sulfonylacetamide with (Z)-2-bromoacrylate yielded the polysubstituted pyroglutamate with three contiguous chiral centers with trans-trans orientation in a one-pot synthesis.The pyrrolizidine skeleton was obtained via the ring-closing metathesis (RCM) method.This facile strategy was used to synthesize (+-)-trachelanthamidine.