Synthesis of 2-arylbenzothiazoles from 2-aminobenzenethiol and aryl aldehydes catalyzed by scandium triflate~1

摘要

2-Aminobenzenethiol and an aryl aldehyde reactded to give a benzothiazoline via an imine intermediate,and the benzothiazoline was aromatized by oxygen or hydrogen peroxide to give a high yield of 2-arylbenzothiazole in the presence of a catalytic amount of scanding triflate Sc(OtF)_3.The intermediary benzothiazoline was isolated adn allowed to react wtih O_2 or H_2O_2 in the presence of Sc(OTf)_3,and the lewis acid was found to also catalyze the oxidative process other than the ring closing step.