BASE-CATALYZED SYNTHESIS OF 1-ARYL-4-(ARYL ETHYL)PIPERAZINES FROM AROMATIC OLEFINS AND 1-ARYL PIPERAZINES

摘要

1-Aryl-4-(arylethyl)piperazine derivatives (I) are prepared by base catalyzed reaction of 1-arylpiperazine derivatives (II) and aromatic olefins (III). Preparation of 1-aryl-4-(arylethyl)piperazine derivatives of formula (I) comprises reaction of a 1-arylpiperazine derivative of formula (II) and an aromatic olefin of formula Ar'CR1=CHR2 (III) in an inert solvent using one or more basic catalysts. Ar, Ar' = optionally fused 6-22C aromatic group or optionally fused 5-22C heteroaromatic group containing at least one ring N, O or S heteroatom; R1, R2 = H, 1-8C alkyl or Ar.