Base-catalyzed synthesis of 1-aryl-4-(aryl ethyl)piperazines from aromatic olefins and 1-arylpiperazines

摘要

A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I) ;by reacting a 1-arylpiperazine of the formula (II) ;with an aromatic olefin of the formula (III); $PTEXTPDATAr\′CR/PDATHILSPPDAT1/PDAT/SP/HILPDAT\═CHR/PDATHILSPPDAT2/PDAT/SP/HILPDAT\ \ (III)/PDAT/PTEXT$ ;in an inert solvent in the presence of at least one basic catalyst, where in the formulae (I) to (III);Ar and Ar′ independently of one another are an aryl radical, selected from the group of the fused and unfused C₆-C₂₂-aromatics and the fused or unfused C₅-C₂₂-heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring; and;R₁ and R₂ independently of one another are a hydrogen atom, a C₁-C₈-alkyl radical or an aryl radical Ar.