BASE-CATALYZED SYNTHESIS OF 1-ARYL-4-(ARYL ETHYL)PIPERAZINES FROM AROMATIC OLEFINS AND 1-ARYL PIPERAZINES

摘要

The invention relates to a method for producing a 1-aryl-4-(aryl ethyl)piperazine of formula (I) by reacting a 1-aryl piperazine of formula (II) with an aromatic olefin of formula (III) Ar'CR1=CHR2 in an inert solvent and in the presence of at least one basic catalyst, whereby in formulas (I) to (III); Ar and Ar', independent of one another, represent an aryl radical selected from the group of the condensed and non-condensed C¿6?-C22-aromatic compounds and of the condensed or non-condensed C5-C22-heteroatoms which contain at least one nitrogen, oxygen or sulfur atom in the ring; R1 and R2, independent of one another, represent a hydrogen atom, a C1-C8-alkyl radical or an aryl radical Ar.