Enantioselective synthesis of the tetrahydrobenzyl-isoquinoline Alkaloid(-)-Norarmepavine using polymer supported reagents.

摘要

We describe,in full,theenantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid(-)-norarmepavine(1) in 77% e.e.This compound was prepared using solid-surpported reagents and scavengers in multi-step sequences of reactions to give materials that required no conventional pruification at th eindvidual steps.