CHEMOSELECTIVE OXIDATION OF 6-HYDROXYALKYLPTERIDINE AND ITS APPLICATION TO SYNTHESIS OF 6-ACYL-7,8-DIHYDROPTERIDINE

摘要

Alcohol-selective oxidation of 6-1'-hydroxyalkylpteridines catalyzed by ruthenium(IV),(RuO4)-,gives 6-acylpteridines in high yields.Partial reduction of the products affords 6-acyl-7,8-dihydropteridine derivatives,such as a lipophilic derivative of sepiapterin,deoxysepiapterin,and sepiapterin-C.