FROM AMINO ACIDS TO POLYCYCLIC HETEROCYCLES-SYNTHESIS OF ENANTIOPURE,FUNCTIONALLY DIVERSE ISOPAVINES AND DIHYDROMETHANODIBENZOAZOCINES

摘要

The intramolecular double Friedel-Crafts condensation of N,N-dibenzyl-O-benzyl-L-threoninal affords a rearranged tetracyclic compound involving a methyl migration.N-Demethylation of tetracyclic isopavines leads to topologically unique secondary amines with potential utility in catalytic reactions as a chiral basic ligand.