Synthesis of new Melationin Analogues from Dimers of Azaidonle and Indole by use of suzuki Homocoupling

摘要

N-{2-[3'-(2-Acetylaminoethyl)-1H,1'H-[5,5']biindol-3-yl]- and N-{2-[1'-(2-acetylaminoethyl)-1'H-[5,5']biindol-1-yl]ethyl}acetamide (2,3) and their analogues in 7-azaindole series (4,5) were synthesized by palladium catalysed reaction starting from indole or 7-azaindole using [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium, as catalyst.