Polycyclic N--heterocyclic compounds. 57 syntheses of fused furo(or thieno)[2,3-b]pyridine derivatives via smiles rearrangement and cyclization

摘要

An efficient methodology for the synthesis of thieno[2,3-c][2,7]-naphthyridine (6),thieno[2,3-c]isoquinoline (11),furo[2,3-c]isoquinoline (14),[1]benzothieno[3,2-d]thieno[2,3-b]pyridine (21),and [1]benzothieno[3,2-d]furo[2,3-b]pyridine (26) skeletons from 4-[o-cyanoarylthio(or oxy)]butyronitriles with base via Smiles type rearrangement reaction followed by the cyclization is described.