DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 7H-THIAZOLO[3,2-b]-l,2,4-TRIAZIN-7-ONE DERIVATIVES AS DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS

Si-Jie Liu; Li-Bo Cui; Hui-Lan Xu

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 7H-THIAZOLO[3,2-b]-l,2,4-TRIAZIN-7-ONE DERIVATIVES AS DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS

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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 7H-THIAZOLO[3,2-b]-l,2,4-TRIAZIN-7-ONE DERIVATIVES AS DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS

机译：双结合位乙酰胆碱酯酶抑制剂7H-噻唑并[3,2-b] -1,2,4-三嗪-7-一衍生物的设计，合成及生物学评价

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A series of 7H-thiazolo[3,2-b]-l,2,4-triazin-7-one derivatives were designed, synthesized and evaluated as dual binding site acetylcholinesterase inhibitors. The target compounds exhibited promising inhibitory activity for AChE. The structure-activity relationships were discussed and their binding conformation and simultaneous interactions mode were further clarified by the molecular docking studies.

机译：设计，合成和评价了一系列7H-噻唑并[3,2-b] -1,2,4-三嗪-7-一衍生物作为双结合位点乙酰胆碱酯酶抑制剂。目标化合物显示出对AChE的有希望的抑制活性。讨论了构效关系，并通过分子对接研究进一步阐明了它们的结合构象和同时相互作用方式。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2013年第12期|共8页
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Si-Jie Liu; Li-Bo Cui; Hui-Lan Xu;
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1. DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 7H-THIAZOLO[3,2-b]-l,2,4-TRIAZIN-7-ONE DERIVATIVES AS DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS [J] . Si-Jie Liu, Li-Bo Cui, Hui-Lan Xu Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2013,第12期

机译：双结合位乙酰胆碱酯酶抑制剂7H-噻唑并[3,2-b] -1,2,4-三嗪-7-一衍生物的设计，合成及生物学评价
2. Design, Synthesis, and Evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one Derivatives as Dual Binding Site Acetylcholinesterase Inhibitors [J] . Sijie Liu, Ruofeng Shang, Lanxiang Shi, Chemical biology and drug design . 2014,第2期

机译：7H-噻唑-[3,2-b] -1,2,4-triazin-7-one衍生物作为双结合位点乙酰胆碱酯酶抑制剂的设计，合成和评价
3. Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors [J] . Leonardo Pisani, Marco Catto, llenia Giangreco ChemMedChem . 2010,第9期

机译：香豆素衍生物的设计，合成和生物学评估拴到作为高强度和选择性双结合位点乙酰胆碱酯酶抑制剂的像drop一样的片段。
4. Design, one-pot synthesis, and evaluation of 7H-thiazolo3,2-b-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors [C] . Si-jie Liu, Lan-xiang Shi, Jing-yu He International Conference on Biotechnology, Chemical and Materials Engineering . 2014

机译：设计，单盆合成和7H-噻唑的评价3,2-B -1,2,4-三嗪-7-一种衍生物作为双重结合位点乙酰胆碱酯酶抑制剂
5. Structure-Based Drug Design in Medicinal Chemistry: I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition [D] . Lee, Minhee 2017

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6. Design synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase [O] . Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, 2021

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7. Design, synthesis, and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as novel acetylcholinesterase inhibitors [O] . Si-jie Liu, a Liu Yang, Zhe Jin, 2009

机译：7H-噻唑并[3,2-b] -1,2,4-三嗪-7-酮衍生物的设计，合成和生物学评价作为新型乙酰胆碱酯酶抑制剂

DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF 7H-THIAZOLO[3,2-b]-l,2,4-TRIAZIN-7-ONE DERIVATIVES AS DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS

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