Regiocontrol in Pd-catalyzed allylic substitution with P,N-ligand

摘要

A racemic ligand, (+-)-N[2-(diphenylphosphino)naphthyl]-2-(pyrrolidinylmethyl) piperidine, has been found to exhibit better regioselectivity than the racemic Pfaltz ligand, BINAP and dppp in the palladium-catalyzed regioselective allylic substitution with the use of (E)-1-phenyl-4-alkoxy-2-butenyl acetate as the substrate.