P-AMINO LIGANDS FROM IMINOSUGARS: NEW READILY AVAILABLE AND MODULAR LIGANDS FOR THE ASYMMETRIC PD-CATALYZED ALLYLIC SUBSTITUTION REACTION

摘要

The synthesis of a new type of amino-phosphite/phosphinite/phosphine ligands containing a protected pyrrolidine-3,4-diol moiety is presented. These ligands are obtained in enantiomerically pure form, from readily available sugars. They thus contain the advantages of carbohydrates in terms of selection of the stereogenic carbons, polyfunctional groups able to modulate the electronic and sterical properties, and the general good stability of carbohydrate derivatives [1-3].