SYNTHESIS OF 3-OXOAZACYCLOHEPT-4-ENES BY RING-CLOSING METATHESIS.APPLICATION TO THE SYNTHESIS OF AN INHIBITOR OF CATHEPSIN K

摘要

The ring-closing metathesis allows the formation of 3-oxoazacyclohept-4-enes from but-3-enamine.By using this methodology,the synthesis of an inhibitor of cathepsin K was achieved in 10 steps from but-3-enamine.Seven-membered ring amino compounds are present in a great variety of natural and non-natural products which possess interesting biological properties.These molecules have stimulated the development of an array of methods for their synthesis.