RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS

摘要

Ring-closing olefin metathesis of acrylates derived from allylic and homo allylic alcohols in the presence of the Grubbs’ catalyst (10–15 mol%) and titanium isopropoxide (0.3–3 equiv) provided ready access to α, β-unsaturated γ- and δ-lactones and an important dipeptide isostere intermediate.