Anabasine as a Precursor for the Synthesis of Potential Agonists of Neuronal Acetylcholine Receptors

摘要

The discovery of specific pharmacological proper ties of epibatidine(I),a potent agonist of neuronal ace tylcholine receptors(N-AChRs),namely,its high non-opioid analgesic activity,has generated interest in the design and synthesis of compounds containing two nitrogen heterocyclic fragments.In particular,the azetidine-substituted pyridine tebanicline(compound ABT-594(II))has been proposed as a highly efficient oral analgesic,while pyrrolidinepyridines(III)attract attention as a basis for the development of neu-ropharmacological agents.