许多植物来源的不同结构的化合物在抗癌药物的发展中起着重要的作用。鬼臼毒素是一种重要的具有抗肿瘤和抗病毒作用的天然来源木脂素类化合物，对它的作用机制已有较详尽的研究，还可以通过化学结构的改造来改善其生物学作用。去氧鬼臼毒素是鬼臼毒素的类似物，已知它也具有抗肿瘤、抗病毒和抗炎的作用。本文对鬼臼毒素和去氧鬼臼毒素在植物中的分布、药理作用、来源等方面进行综述，为鬼臼毒素类抗肿瘤药物研发提供文献依据。% A number of plant-derived compounds have played significant roles in the development of several potent anticancer drugs. Podophyllotoxin is a naturally occurring lignan with important antineoplastic and antiviral properties and supported by detailed understanding of their mechanism of action,and facilitated by chemical manipulations that have amplified their bioactivity. Deoxypodophyllotoxin,analogue of podophyllotoxin,is well known for its antitumor,antiviral,and anti-in?ammatory activities. The aims of the present review is to present the nowadays status of podophyllotoxin and deoxypodophyllotoxin,their distribution, applications,biosynthesis,chemical synthesis and biotechnological sources.
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