Novel Binary Compounds Derived from 1,2,4-Thiadiazole

摘要

The design of multifunctional pharmaceuticals with a broad spectrum of activity that are capable of interacting with several targets is one of the promising directions of contemporary medicinal chemistry. Recently, molecules containing pharmacophoric thia-diazole fragment and showing interesting pharmaceutical properties [1], including neuroprotective [2], have attracted much attention as promising therapeutics. In continuation of our studies, we developed a method of synthesis of 1,2,4-thiadiazole derivatives containing biogenic amines as a second pharmacophore or nitroxy group as a nitrogen oxide NO producer. We showed recently that N,N-disubstituted 5-amino-3-(2-nitroxypropyl)-l,2,4-thiadiazoles are efficient blocators of glutamate-stimulated ~(45)Ca~(2+) uptake [3] and, therefore, can affect pathological processes in different neurodegenerative diseases [4].