Palladium-Catalyzed Reactions of Halogen Derivatives of N,N- Dimethyl- 1-Phenylethanamine with Arylboronic Acids as a Novel Approach to the Synthesis of Biaryls with Central and Axial Chirality

摘要

Biaryls with axial chirality (atropoisomerism), which appears due to hindered rotation around the Ar-Ar bonds in the presence of at least one bulky sub-stituent in the ortho-position, occur as structural units in some natural molecules . Examples of these compounds are the antibiotic vancomycin , the antitumor lignan steganacin , and the anti-HIV agent Michelamine B. Furthermore, biaryl derivatives with axial chirality are widely used in the catalytic asymmetric synthesis as efficient ligands.