In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor

Xue Xuling; Fang Hongbao; Chen Huachao; Zhang Changli; Zhu Chengcheng; Bai Yang; He Weijiang; Guo Zijian

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In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor

机译：新型NIR荧光传感器对活小鼠体内的Cu2 +进行体内荧光成像

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Modifying the BODIPY fluorophore with a 4-aminostyryl group forms a NIR fluorescent Cu2+ sensor with a large Stokes shift, high photostability and a high quantum yield. The in vivo Cu2+ fluorescence imaging in live mice was realized for the first time with this sensor, profiting from its reduced self-absorption and minor photobleaching. (C) 2016 Elsevier Ltd. All rights reserved.

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《Dyes and Pigments》 |2016年第null期|共6页
作者
Xue Xuling; Fang Hongbao; Chen Huachao; Zhang Changli; Zhu Chengcheng; Bai Yang; He Weijiang; Guo Zijian;
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正文语种 eng
中图分类染料及中间体工业;颜料工业;
关键词
Near infrared; Copper ions; Fluorescence imaging; Cell; Mice;

机译：近红外;铜离子;荧光成像;细胞;小鼠;

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1. In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor [J] . Xue Xuling, Fang Hongbao, Chen Huachao, Dyes and Pigments . 2016,第Null期

机译：新型NIR荧光传感器对活小鼠体内的Cu2 +进行体内荧光成像
2. John Wiley & Sons, Ltd. NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging [J] . Kazuki Aita, Takashi Temma, Yuji Kuge, Luminescence: The journal of biological and chemical luminescence . 2010,第1期

机译：John Wiley＆Sons，Ltd.用于体内荧光分子成像的NIR荧光fluorescent化合物
3. Complete suppression of the fluorophore fluorescence by combined effect of multiple fluorescence quenching groups: A fluorescent sensor for Cu2+ with zero background signals [J] . Long Lingliang, Wu Yanjun, Wang Lin, Analytica chimica acta . 2016,第Null期

机译：通过多个荧光猝灭基团的组合作用完全抑制荧光团荧光：零背景信号的Cu2 +荧光传感器
4. In Vivo Time-Resolved Fluorescence Imaging of a NIR FRET Probe in Live Mice [C] . Zhao Lingling, Abe Ken, Barroso Margarida, Annual Northeast Bioengineering Conference . 2013

机译：NIR FRET探针在活小鼠中的体内时间分辨荧光成像
5. Design of magnetic and fluorescent nanoparticles for in vivo MR and NIRF cancer imaging. [D] . Key, Jaehong. 2012

机译：用于体内MR和NIRF癌症成像的磁性和荧光纳米粒子的设计。
6. Highly Biocompatible Nanoparticles of Au@Fluorescent Polymers as Novel Contrast Agent for In Vivo Bimodality NIR Fluorescence/CT Imaging [O] . Mengshu Zhang, Jinlei Liu, Guannan Wang 2019

机译：具有高度生物相容性的Au @荧光聚合物纳米粒子作为体内双峰NIR荧光/ CT成像的新型造影剂
7. Figure 9: A was acquired at one minute, and B was acquired six hours after the initial fluorescent imaging, the fluorescent signal intensity in the tumor area has no significant difference from other areas of the body expect the liver and spleen. C was acquired 24 h after injection, the fluorescent signal could not be visualized in the mice. D, E and F were acquired from experiments of mice with Huh-7 xenograft tumors blocked using GPC3 antibody presented the same fluorescent imaging characteristics as those in the mice with Huh-7 xenograft tumors. [O] . -1

机译：图9：在初始荧光成像后六个小时获得了1分钟的A，肿瘤区域中的荧光信号强度与肝脏和脾脏的其他区域没有显着差异。注射后24小时获得C，荧光信号不能在小鼠中可视化。从使用GPC3抗体封闭的Huh-7异种移植肿瘤的小鼠实验中获取D，E和F，呈现与Huh-7异种移植肿瘤的小鼠中的荧光成像特性相同的荧光显像特性。

In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor

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