Dopamine D1 receptor gene polymorphism is associated with myocardial infarction. (Special Issue: Special focus on undergraduate research.)

摘要

Dopamine D1 receptor (DRD1) gene is associated with the pathogenesis of myocardial infarction (MI) in aspects of plaque rupture, platelet aggregation, and neutrophil-mediated injury of cardiac myocytes. Thus, the study was designed to explore whether the A-48 G polymorphism of the DRD1 gene was associated with MI. The genotype of the DRD1A-48 G polymorphism was determined by polymerase chain reaction in the 602 Han Chinese participants, 255 MI patients and 347 controls without MI. A significant association was found between the A-48 G polymorphism of DRD1 and MI (genotype model: chi 2=13.2, unadjusted p=0.001; chi 2=13.9, adjusted p=0.0002; dominant model: adjusted OR 2.05, 95%CI 1.40-3.00, p=0.0002; recessive model: adjusted OR 2.34, 95%CI 1.01-5.39, p=0.047). The G allele was a risk-increased allele for MI (unadjusted OR 1.83, 95%CI 1.34-2.50, p=0.0001; adjusted OR 1.94, 95%CI 1.40-2.68, p=0.00007). Thus, the study demonstrated the significant association between A-48 G polymorphism of the DRD1 gene and MI.Digital Object Identifier http://dx.doi.org/10.1089/dna.2011.1466