[Cardiogenic shock].

摘要

The AHS is a serious iatrogenic disease. 2?% of the treated patients develop a skin rash. 0,4?% of these patients experience suddenly and unforeseen a severe hypersensitivity with a mortality of 14-30?%. An early diagnosis is often very difficult. In the pathogenesis different causes are discussed. A hereditary component is involved. Of essential importance is the amount of the starting dose, the kidney function and concomitant drugs. In an asymptomatic hyperuricaemia the application of allopurinol is not indicated. If strong indications are present, the allopurinol therapy has to start with the lowest dose (100?mg/d). If required this dose should be increased under consequent supervision only.