KNOCKING Down Disease New uses of RNAi might transform all of its possibilities into realities.

摘要

The discovery and application of RNA interference (RNAi) have already fundamentally changed our understanding of biology. The ability to "knock down" the expression of specific genes of interest has helped researchers decipher how genes or gene networks contribute to biological and pathological processes. Recently, the activity of synthetic small interfering RNA (siRNA) has created great interest in developing a new class of drugs based on RNA therapeutics.