Evaluation of fecal myeloperoxidase as a biomarker of disease activity and severity in ulcerative colitis.

摘要

Subclinical inflammation in ulcerative colitis (UC) can predispose to relapses and biomarkers can detect mucosal inflammation.To study the role of fecal myeloperoxidase (FMPO) in assessing disease activity and response to therapy in UC.Patients with UC attending our hospital from July 2005 to September 2006 were studied. All patients underwent clinical, endoscopic, and histological assessment for disease extent and severity. Estimation of FMPO levels at baseline and on follow-up was carried out. Age-matched healthy controls were studied for FMPO levels.A total of 55 patients of UC (30 males, 25 females, mean age 38.6?±?12?years) and 54 age-matched controls (mean age 37.6?±?13.6 years) were studied. Cases had higher median MPO levels than controls (0.42 [IQR 0.84] vs. 0.06 [IQR 0.12]); (p?