OMICRON-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity

摘要

From the aerial parts of Geranium pyrenaicum Burm.,a new flavonol glycoside,kaempferol 3-OMICRON-(2",3"-di-OMICRON-galloyl)-beta-D-glucopyranoside(7),along with 6 known related glycosides [kaempferol 3-OMICRON-beta-D-glucopyranoside(1),quercetin 3-OMICRON-beta-D-glucopyranoside(2),quercetin 3-OMICRON-beta-D-galactopyranoside(3),kaempferol 3-OMICRON-(2"-OMICRON-galloyl)-beta-D-glucopyranoside(4),quercetin 3-OMICRON-(2"-OMICRON-galloyl)-beta-D-glucopy-ranoside(5)and quercetin 3-OMICRON-(2",3"-di-OMICRON-galloyl)-beta-D-glucopyranoside(6)] and the ellagitannins co-rilagin(8)and tellimagrandin I(9)were isolated.Their structures were established from spectroscopic studies(UV,FAB-MS,:H and ~(13)C-NMR,~1H-~1H COSY,HETCOR,HMBC).Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species(L.major,L.donovani and L.amazonensis),indicating appreciable in vitro activities(IC_(50)4-27 nM)when compared with Pentostam(IC_(50)10-11 nM).