An efficient and green approach for the synthesis of vinyl aryl ethers in the presence of guanidine hydrochloride

摘要

A stereoselective procedure for vinyl aryl ether bond formation by direct coupling of dialkyl acetylenedi-carboxylates and substituted phenols or naphthols under mild reaction conditions has been developed. Using guanidine hydrochloride as a new catalyst and water-acetone as green solvent, dialkyl acetylenedicarboxy-lates were reacted with substituted phenols or naphthols in room temperature to produce vinyl aryl ethers in good to excellent yields.