Direct reductive animation of carbonyl compounds using sodium borohydride-silica chloride

摘要

A simple and convenient procedure for reductive animation of aldehydes and ketones using sodium borohydride in the presence of silica chloride as an active, inexpensive, recoverable, and recyclable catalyst is described. The reactions were carried out with equimolar amounts of amine and carbonyl compound using silica chloride-sodium borohydride in THF at room temperature.