Synthesis,Crystal Structure and Antifungal/Antibacterial Activity of Some Novel Highly Functionalized Benzoylaminocarbothioyl Pyrrolidines

摘要

A series of novel highly functionalized benzoylaminocarbothioyl pyrrolidines were prepared from ben-zoylisothiocyanate and substituted pyrrolidines in excellent yield.The crystal structure of the novel 1-benzoylaminocarbothioyl-5-(naphthyl)-pyrrolidine-2,3,4-tricarboxylicacid trimethyl ester(3a)was determined by X-ray crystal structure analysis.The synthesized compounds were characterized and screened for their in vitro antibacterial and antifungal activities and toxicity.The prepared compounds were tested against the standard strains:Escherichia coli(ATCC 25922),Enterobacter cloacae(ATCC 13047),Ente-rococcus faecalis(ATCC 29212),Pseudomonas aeruginosa(ATCC 27853),Staphylococcus aureus(ATCC 29213)and Staphylococcus epidermidis(ATCC 12228)and the yeasts Candida albicans(ATCC 90028),Candida krusei(ATCC 6258),Candida parapsilosis(ATCC 22019),Candida tropicalis(ATCC 22019)and Candida glabrata(ATCC 32554).