Hybrid Capture 2 Human Papillomavirus Testing of Fine Needle Aspiration Cytology of Head and Neck Squamous Cell Carcinomas

摘要

Background: Human papillomavirus (HPV) positive head and neck squamous cell carcinoma (HNSCC) accounts for 25% of HNSCCs and frequently presents with neck lymph node metastases. We investigated utilizing cytology needle rinse material for HPV DNA testing by Hybrid Capture 2 molecular testing (HC2) as an alternative to p16 immunohistochemistry.