Phosphatidic acid: a new therapeutic lead to suppress hepatic glucose production

摘要

We view studying rare diseases with metabolic complications, like lipodystrophy, could also be a window into understanding the pathophysiol-ogy of more common diseases, such as Type 2 diabetes (T2D). The liver is the most important organ in mammals for glucose homeostasis. Upon meal ingestion, insulin is released from the pancreas (P cells) and suppresses the liver glucose production while at the same time increasing the glucose uptake by the skeletal muscles and adipose tissue. This relationship is altered in T2D. T2D patients develop insulin resistance and thus the ability of insulin to suppress liver glucose production is reduced.