Evidence childhood epidemics of type 1 and type 2 diabetes are opposite extremes of an immune spectrum disorder induced by immune stimulants. Role of race and associated cortisol activity as a major determining factor of the type of diabetes

摘要

Design: Prior publications have provided evidence that type 1 and type 2 diabetes are opposite extremes of an immune spectrum disorder. Method: The risk of type 1 diabetes was correlated with the risk of type 2 diabetes in different races. Results: Races with high risk of developing type 2 diabetes have an decreased risk of developing type 1 diabetes (correlation coefficients -0.5 or -0.85 depending on age, p < 0.05). Maori, American Indians, Asians, Australian Aboriginals and US Black children have a higher risk of developing type 2 diabetes but a low risk of type 1 diabetes compared to White children. Conclusion: Population data is consistent with type 1 and type 2 diabetes being opposite ends of an immune spectrum disorder.