Successful treatment of refractory skin manifestations of systemic lupus erythematosus with rituximab: report of a case.

摘要

Skin disease is a frequent clinical manifestation of systemic lupus erythematosus (SLE) and may occasionally be one of its most refractory clinical manifestations [1-3]. B-cell-depleting therapy with rituximab (monoclonal anti-CD-20 antibody) is emerging as a novel treatment for rheumatoid arthritis and different types of vasculitis . We report a case of SLE with extensive and therapy-resistant subacute cutaneous lupus erythematosus (SCLE) that was successfully treated with rituximab.