Dinuclear nickel(II)complexes of reduced asymmetric compartmenta] ligands

摘要

X-Ray crystallographic studies on urease isolated from different sources [Klebsiella aerogenes and the native and inhibited metalloenzyme from Bacillus pasterii] have provided a detailed description of the active site(Fig.1).The dinickel(II)centre has each nickel(II)ion ligated by two histidine residues from the protein and a carbamylated lysine residue bridges the nickel(II)ions.Ni(2)is further ligated by an aspartate residue and two terminally coordinated water molecules and one bridging water molecule,or hydroxide ion completes the coordination environments at the metal ions.