Synthesis,crystal structure and chemical stability of bismuth(III)complexed with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid(H_8DOTMP)

摘要

The potential use of the alpha-particle emitting compounds ~(212/213)Bi-DOTMP and ~(212)Pb-DOTMP in therapy of bone-associated cancers,and medical interest in bismuth compounds,motivated this study.Syntheses of the Bi(III)and Pb(II)complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid(H_8DOTMP)are reported.Extensive pH-stability was found for both complexes,in the pH range 0-13 for Bi-DOTMP and pH 4-14 for Pb-DOTMP.Furthermore,both complexes formed within 1 min in the pH range 6-10 at 10 muM metal-ion and 15 muM DOTMP.Single crystals of [NaBi(H_4DOTMP)] and polycrystalline [Bi(H_sO_2)(H_4DOTMP)] were formed and characterized by single crystal and powder X-ray diffraction methods,respectively.The structure of the anion was found in both salts to exhibit a square antiprismatic eight-coordination with a four-fold axis of symmetry.