A dinuclear nickel complex modeling of the Ni-d(II)-Ni-p(I) state of the active site of acetyl CoA synthase

摘要

The dinuclear Ni(II)-Ni(I) complex Ni-II(dadt(Et))Ni-I(SDmp)(PPh3) was synthesized as a Ni(II)(d)-Ni(I)(p) model of the Acluster in acetyl CoA synthase. This complex was reacted with Co(dmgBF(2))(2)(Me)(Py) and KSDmp successively to afford Ni(dadt(Et))Ni(Me)(SDmp), which further reacts with CO to afford the acetylthioester CH3C(O)SDmp via reductive elimination.